Nuclear expression of Ku70/80 is associated with chek2 germline mutations in breast cancer
نویسندگان
چکیده
AMA Jakub R, Filip M, Daniel B, et al. Nuclear expression of Ku70/80 is associated with chek2 germline mutations in breast cancer. Polish Journal Pathology. 2023. doi:10.5114/pjp.2023.129518. APA Jakub, R., Filip, M., Daniel, B., Jolanta, H., Tomasz, & Cezary, C. (2023). https://doi.org/10.5114/pjp.2023.129518 Chicago Rosik, Machaj Bodnar Hybiak Huzarski Cybulski and Lubiński Jan "Nuclear cancer". Harvard C., Jan, L., Wenancjusz, D., Domagała, P. MLA Rosik cancer." Pathology, Vancouver Jolanta H, Tomasz Cezary C
منابع مشابه
Breast cancer risk associated with CHEK2 mutations.
Most efforts to identify individuals who have a hereditary predisposition for developing breast cancer had focused on the BRCA1 and BRCA2 genes. Less common susceptibility genes also are associated with increased risk for developing breast cancer, but until recently have often gone undetected. With the advent of next generation sequencing (NGS), many families with suspected hereditary risk are ...
متن کاملGermline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
BACKGROUND Germline mutations in BRCA1 and BRCA2 genes account for only 20-40% of familial breast cancer cases. The CHEK2 gene encodes a checkpoint kinase, involved in response to DNA damage, and hence is a candidate gene for breast cancer susceptibility. Indeed, the CHEK2*1100delC truncating mutation was reported in a subset of mostly North European breast cancer families. The rate of the CHEK...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولGermline mutation of microRNA-125a is associated with breast cancer.
MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a i...
متن کاملAPOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population
Breast Cancer (BC) is considered as one of the most important causes of death worldwide. Previous studies showed that apolipoprotein B mRNA- editing catalytic polypeptide-like 3 (APOBEC3) gene deletion significantly increased the risk of BC risk in Chinese and European women. The present study aimed to assess the possible impact of APOBEC3 deletion and the risk of BC in a sample of Iranian popu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polish Journal of Pathology
سال: 2023
ISSN: ['2084-9869', '1233-9687']
DOI: https://doi.org/10.5114/pjp.2023.129518